The band will perform for competition winners on September 25th.
As part of the month-long festival, which features performances every night in September, Pixies will play at London's Roundhouse with support from NO CEREMONY///.
A short statement from the band simply reads: "We're excited to be back on tour in Europe and performing at the iTunes Festival in London."
Other acts on the bill include Queens Of The Stone Age and Primal Scream. All tickets are free but fans must apply for the chance to win them at www.itunesfestival.com.